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It is also involved in bone mineralization and the prevention of vascular calcification and coronary heart disease (92)

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The current clinical evidence of intravenous glutathione for skin lightening is limited to a single study with a dubious study design and apparently flawed analysis of results, casting doubt on the drugs efficacy and reported adverse effects
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Targeting GST therefore provides a mechanistically relevant way to evaluate whether microbes-derived metabolites can interfere with this detoxification system and potentially sensitise bacteria to existing antibiotics

For researchers developing small-molecule inhibitors, nucleic acid therapeutics, uricosuric agents, or anti-inflammatory biologics, choosing the right animal model can directly influence the interpretability and translational value of preclinical data
