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On the other hand, the activation of ACE2 receptors limits activated microglia polarization to the M1 phenotype and shifts its polarization to the M2 anti-inflammatory phenotype [355], which demonstrates the critical role of the renin-angiotensin system (RAS) in neuroinflammation

Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats

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(2016) Enhanced arsenic sensitivity with excess phytochelatin accumulation in shoots of a SULTR1;2 knockout mutant of Arabidopsis thaliana (L.) Heynh

This complex biological process involves multiple cellular and molecular mechanisms, mainly characterized by the activation of glial cells, especially microglia, which are the resident immune cells of the CNS [31,32]

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