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[1] If clinical suspicion is high, particularly with subacute combined degeneration, treatment should commence immediately as delays may result in irreversible damage

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These symptoms typically resolve within 24 hours.* Not for Everyone: This therapy is not recommended for individuals allergic to cobalamin (B12), those with liver disease, or those currently taking medications that interact with methyl donors

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Imaging demonstrates various manifestations, including diffuse abnormalities in the supratentorial white matter, reduced brain volume, diffuse cerebral edema, basal ganglia calcifications, and delayed myelination [78, 79]

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