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Regulation of calcium fluxes by GPX8, a Type-II transmembrane peroxidase enriched at the mitochondria-associated endoplasmic reticulum membrane

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The accumulation of AEGs and their binding to the receptor for glycosylation end-products (RAGE) promotes oxidative stress, which activates the NF-B signalling pathway, upregulates the expression of target genes and triggers inflammation (22)

By binding to the subunit of the IL4 receptor, it effectively blocks downstream signaling of IL4 and IL13, thereby inhibiting the Th2 inflammatory signaling pathway and corresponding cytokines [196]

Updated 6/26/2019