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Description
Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: a retrospective review from a single center

4.3 Consequences of mtDNA damage: from bioenergetic crisis to immune exhaustion mtDNA mutations and depletion impair the synthesis of essential ETC components, resulting in defective OXPHOS, reduced ATP synthesis, collapse of the mitochondrial membrane potential (m), and accumulation of metabolic intermediates due to TCA cycle disruption and compensatory glycolysis

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Like most antimicrobial peptides, LL-37 comes from monocytes, neutrophils, and macrophages

They are restorative, not explosive

Ferroptosis has been implicated as a potential pathogenic factor in IBD [18]
