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Glutathione Forms Compared Oral Safety: Excellent Evidence: Strong Side Effects: Minimal (mild GI) Topical Safety: Good Evidence: Moderate Side Effects: Localized only IV (Intravenous) Safety: Poor Evidence: Weak/Flawed Side Effects: Serious risks Myth vs

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Despite substantial experimental evidence supporting this notion, challenges such as low solubility, limited bioavailability, and BBB impermeability hinder efficient delivery of EGCG to the brain and impede clinical translation (173)