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The pathogenesis of MASLD is complex and progressive, the liver histopathological diagnosis of MASLD is difficult to achieve in humans and suitable experimental models must be established to study MASLD, thus posing great challenges to its prevention and drug development

10.1016/j.ctim.2017.05.006

2020;37(8) Colitti M, Gaspardo B, Della Pria A, Scaini C, Stefanon B

Circ Res 94:14831491 Zhang Y-J, Wang W, Yang H-L, Li Y, Kang X-Y, Wang X-R, Yang Z-L (2015) Molecular properties and functional divergence of the dehydroascorbate reductase gene family in lower and higher plants

Moreover, SLNs could also be tailored like dendrimers and liposomes to ensure the crossing through the BBB, which remains a major challenge for neurologists who treat PD (97)

Schultheis et al
