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But under oxidative stress conditions induced by reactive species, toxins or ARE inducers, the association between Nrf2 and Keap1 is disrupted and Nrf2 translocates to the nucleus of the cell, where it binds to small Maf proteins that increase the transcription of genes driven by ARE [67]

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When patients experience swollen lymph nodes during tirzepatide treatment, clinicians should conduct a comprehensive differential diagnosis rather than assuming medication causation

10.1016/j.regpep.2009.05.008 [DOI] [PubMed] [Google Scholar] 20

Then, CETSA western blotting showed that cell lysates treated with PQS (T m = 58 C) had a T m shift of 12 C relative to lysates treated with DMSO (T m = 46 C) (Fig

Thinking through these factors transforms a simple question about location into a robust and well-designed research strategy