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Transgenic mice overexpressing intestinal Cldn1 have been used to demonstrate consequent induction of MMP9 and pERK signalling and Notch-signalling pathway activation, leading to inhibition of goblet cell differentiation, decreased Muc2 expression and resultant mucosal inflammation (96)

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At the same time: most peptide therapies discussed for injury recovery are still considered experimental and have not yet reached the level of evidence required for routine clinical use

However, we do not adjust for future changes in such variables as number of visits or case-mix

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