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Dysfunctional mitochondria with excessive ROS, abnormal calcium and potassium ion mobilization, and unusual ATP or NAD + levels can trigger immune response [132]

G.SchaeferM.HarteneckC.GudermannT.SchultzG

[DOI] [PMC free article] [PubMed] [Google Scholar] Wiegand D

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This anatomical arrangement means that an orally absorbed drug must pass through two major sites of potential metabolism before reaching the systemic circulation