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[DOI] [PMC free article] [PubMed] [Google Scholar] Michels L.R., Fachel F.N.S., Schuh R.S., Azambuja J.H., de Souza P.O., Gelsleichter N.E., et al

The peptide activates the FAK-paxillin pathway in fibroblasts, enhancing cell migration, survival under oxidative stress, and collagen synthesis critical for structural tissue repair

Contrary to CHAOS, the HOPE trial failed (Yusuf et al

Its analgesic effects were comparable to that of morphine, but notably, LPF-35 did not induce tolerance or dependence, suggesting a non-opioid mechanism of actionpossibly through local anti-inflammatory effects and modulation of nociceptive signaling at nerve endings and ion channels