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Density and wrinkle changes appear at 8 to 12 weeks

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PubMed Ho, E.N., Kwok, W.H., Lau, M.Y., Wong, A.S., Wan, T.S., Lam, K.K., Schiff, P.J., Stewart, B.D

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By the age of three, all typical symptoms such as impaired social reciprocity, poor communication skills and restricted for repetitive behavior, affecting three major domains are observed