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The FDA also provides additional supportive information via Section 6 of Validation of Automated Process Equipment and Quality System Software in the Principles of Software Validation

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Stimulation of ILC2s To obtain a sufficient number of ILC2s, mice were intranasally administered with recombinant mouse IL-33 (mrIL-33, Novoprotein, China) at a dosage of 400 ng in 50 L of saline for 5 days