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R023 mainly interacts through its variable light (L) chain domain (V L ) with the HLA, while its variable heavy (H) chain domain (V H ) is mostly involved in hapten recognition 33

The in vitro component demonstrated that both glucagon and Retatrutide directly decreased ANGPTL3/8 secretion from hepatocytes, and this effect was blocked by a glucagon receptor (GCGR) antagonist