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In BV2 microglial cell lines subjected to lipopolysaccharide (LPS)-induced neuroinflammation, both lactylation-mediated inhibition of p53 activity and direct knockdown of p53 protein can disrupt the control of the NF-B inflammatory signaling pathway, ultimately leading to abnormal expression of pro-inflammatory factors and M1 polarization of microglia [132]

Overexpression of MAT1A increases SAM levels, which induces ferroptosis of HCC cells through increased CD8 + T cell cytotoxicity and IFN- expression [120]

Moreover, in aging-related research, ROS have been star molecules, stemming from their continuous impact on tissue aging

[PubMed] [Elsevier] 21

Almost 90% of DPPH was scavenged by 4-MESC at 500 M concentration (Figure 2A)

Oxidative stress is a situation when intracellular levels of reactive oxygen species (ROS) are enhanced, which leads to the disruption of cellular metabolism and damage to lipids, carbohydrates, proteins and nucleic acids