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Here we report the identification of irreversible, thiol-reactive diazepam derivatives as GPX4 modifiers and nanomolar inducers of ferroptosis in liver cancer cells

Examples include mexiletine, flecainide, and amiodarone

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9 Conversely, hypothyroidism suppresses metabolic rate and can result in weight gain, dyslipidemia, cold intolerance, depression, fatigue, and hyporeflexia

Studies of blood and urine metabolomics in children with autism versus controls have shown that although fewer metabolisms show consistent changes across studies, the mechanisms by which they are associated are convergent and correlate with common pathogenesis and pathophysiological changes in ASD