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The novel mechanism by which 4-HNE inhibits NLRP3 is through its ability to directly bind to the critical domains of NLRP3, disrupting its interaction with the adapter protein NEK7, a key step in inflammasome activation, thereby preventing caspase-1 activation

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Activation of type I and III interferon response by mitochondrial and peroxisomal MAVS and Inhibition by hepatitis C virus

[PMID: 26389333] Images in this summary are used with permission of the author(s), artist, and/or publisher for use within the PDQ summaries only

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Back in Buffensteins officewhere the curtains, throw blankets, and mugs all wear her rats toothy expressionsshe flips her computer open to a PowerPoint presentation