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If you let it go for too long, it can cause problems in your nervous system such as: Vision problems Memory loss A pricking or numbing sensation Difficulty speaking or walking due to ataxia (loss of physical coordination) Damage to your extremities (hands, feet, arms, etc.), particularly your legs Other problems could include Infertility (this should go away with B12 treatment) Stomach cancer Bleeding and infections Damage your heart, brain, bones, and other organs in your body If you're pregnant and don't get enough vitamin B12, your baby is at risk of a serious birth defect called a neural tube defect

Under physiological conditions, elastase plays an important role in wound healing by degrading damaged tissue and enabling full regeneration, but its excess can disrupt the balance between tissue degradation and remodeling [248,249,250]

For example, Evrova et al

It depends on the cause of deficiency

Journal of Laboratory and Clinical Medicine 136, 2000

The degree of displacement can produce obstructive symptoms, as occurred in this patient, and may increase the risk of volvulus