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Due to their inherent properties, different classes of metabolites require optimized extraction methods, which should be standardized in order to provide a direct comparison between results generated in different laboratories

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For example, deletion of KDM6A results in accelerated tumorigenesis and acquisition of an aggressive transcriptional subtype 9597

By contrast, loss of G6PD activity was found to be beneficial in many disease models by limiting generation of high NADPH levels and reductive stress