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After the excess BMH has been washed away, the maleimide at the other end can react with a sulfhydryl group on a ligand

Additionally, IPA functions as an allosteric inhibitor of TrpE by mimicking tryptophan, blocking the catalytic step of tryptophan synthesis mediated by TrpE, thus disrupting metabolic pathways in pathogens such as Mycobacterium tuberculosis and suppressing their proliferation (91)

[DOI] [PMC free article] [PubMed] [Google Scholar] 356.Swartz K.J., Matson W.R., MacGarvey U., Ryan E.A., Beal M.F

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