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Increasingly, human trials demonstrate distinct responder and non-responder subgroups, even when participants receive the same strain and dosage, with differences correlated to baseline microbial community structures, metabolic profiles, and gut transit characteristics (573)

Oral/injectable forms (investigational) risk GI upset or hypercupremia

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For mild-to-moderate UC, oral administration of curcumin (1500 mg/day) can significantly reduce the scores on the Simple Clinical Colitis Activity Index, IBD Questionnaire-9, and quality of life of UC patients [256]

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Impurities such as truncated peptides, deletion sequences, and racemization byproducts are common in low-cost peptide production