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Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

doi: 10.1016/0304-4165(78)90037-5

Statements Author contributions BD wrote this review and MV and JP revised it

This assay detects stage I cancer with 95% sensitivity (95% confidence interval), 100% specificity, and 68% accuracy (Liu et al., 2019)

These areas can have extreme or fluctuating temperatures

These studies offer new directions for stroke treatment, and future research should explore the best timing and dosage of these interventions to maximize their effectiveness