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In conclusion, as shown in Fig S1, the activation of eNOS by BPC 157 is mediated through multiple regulation processes including the promotion of VEGFR2 activation and endocytosis, the activation of positive regulator AKT, the reduction of the interaction of negative regulator Cav-1 with eNOS

Phillipson M, Kubes P

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For MAPK pathways, KPV inhibits all three subfamilies: ERK1/2 (extracellular signal-regulated kinases) JNK (c-Jun N-terminal kinases) p38 MAPK Phosphorylation of these kinasesrequired for activationdrops markedly in cells exposed to KPV