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Moreover, CD38 deficiency-mediated inhibition of the biogenesis, secretion, and internalization of SA-sEVs by senescent VSMCs was partially involved in reestablishing the function of the mitochondrial-lysosomal axis in smooth muscle cells

S., Marttinen A., Puolakka T

Chemical Biology & Drug Design, 81(1), 136-147
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The severity and duration of deficiency are perhaps the most significant factors
