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105 The decreased secretion of nutrient factors by bone marrow stromal cells can result in an enhanced differentiation of HSCs into myeloid cells and a reduced differentiation into lymphocytes

And that Connectivity Map gene profiling is, frankly, hard to ignore for anyone working in regenerative or age-related research

JCI Insight 2(12):e93411

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Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks