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This effect is stark in HF with preserved ejection fraction (HFpEF), where stiff ventricles increase pressures during exertion, causing ventilationperfusion (VQ) mismatch and reduced exercise tolerance, often exacerbated by pulmonary arteriolar remodeling

High blood pressure, or hypertension, affects millions of people worldwide and is a significant risk factor for heart disease and stroke

MicroRNAs and endothelial (Dys) function

Effects of Oral L-citrulline supplementation on lipoprotein oxidation and endothelial dysfunction in humans with vasospastic angina

In addition to the transcellullar mechanisms described here, molecules may pass via the paracellular route, discussed in further detail below (Fig
