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Additionally, puerarin was reported to directly benefit diabetes mellitus and a series of complications by decreasing blood glucose levels, improving insulin resistance, protecting islets, inhibiting inflammation, decreasing oxidative stress, and inhibiting Maillard reaction and advanced glycation end products (AGEs) formation [281]

However, the exact intracellular mechanism that contributes to inducing this oxidative stress is not completely understood ( Iron has been discovered to play a part in APAP-caused hepatotoxicity

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doi: 10.1146/annurev-immunol-042718-041812 68 CourtiesGHerissonFSagerHBHeidtTYeYWeiYet al
