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Benfotiamine in the treatment of diabetic complications Diabetes may be regarded as a thiamine deficient state, specifically because of the important role of ThDP as a cofactor for crucial enzymes in intracellular glucose metabolism that is amplified in this disease [77]

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SAH is the metabolic precursor of homocysteine (Hcy) and also acts as a negative regulator of all methyltransferases mentioned above [34]

[0022] The number of tablets to be administered daily will be decided by the physician also in relation to different factors connected with the condition of the patient

Therefore, there is a pressing need to characterize new drug targets and drugs against them

Prawitt, J., Caron, S