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Sunitinib Sunitinib (Sutent ) is a novel oral multitargeted TKI of VEGFR-1, VEGFR-2, fetal liver tyrosine kinase receptor 3, c-KIT, PDGFR-, and PDGFR- (Yardley et al., 2012)

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Mechanistically, this beneficial effect seems to be mediated by the regulation of intracellular Ca 2+ levels by the modulation of calbindin expression, which is associated with calcium homeostasis and plays a role in the protection of dopaminergic neurons in the pathogenesis of PD (Liu et al., 2014)