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In 1924, Otto Warburg observed a curious phenomenon that, unlike other normal cells in vivo, cancer cells prefer glycolysis rather than aerobic respiration even under the condition that the oxygen is sufficient [6]

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Collectively, HDL induced cell signaling in vascular and inflammatory cells underlies HDLs anti-atherogenic properties in health, and deficits in HDL signaling likely link HDL dysfunction in metabolic diseases to increased risk of atherosclerosis

The methods for the characterization of the DMF targetome are based on mass spectrometry and are outlined below

Nature 471 , 513517 (2011)

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