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Astrocytes provide neurons with the required cysteine in a process that involves export of GSH from astrocytes, the extracellular processing of GSH via the astrocytic glutamyl transpeptidase (GT) to generate the dipeptide cysteinylglycine (CysGly) and the extracellular cleavage of this dipeptide by the neuronal ectopeptidase aminopeptidase N (Figure 1)

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