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It is relevant to note that ER and SERMs are linked to the serotonergic system function [42,44,76,77]

& Niijima, A

In a recent smaller phase 1b study the non-steroidal, fexeramine-derived FXR agonist MET409 improved fat content (MRI-proton density fat fraction (PDFF)) over 12 weeks113 and is further evaluated alone or in combination with empagliflozin (SGLT2 inhibitor) in patients with both NASH and type 2 diabetes (NCT04702490)

doi: 10.1016/j.fsi.2024.109795 8 AmoahK.DongX.TanB.ZhangS.KuebutornyeF

doi: 10.1007/s10311-018-0734-7

uPAR is a cancer-selective membrane protein, ICG is a clinically approved near-infrared (NIR) dye, and FVIOs are well-characterized nanorings with high efficiency in heat conversion under alternating magnetic field (AMF)
