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The vitamin can be stored in the liver for a long time, so it may take a few years for a deficiency to develop ( Summary Vitamin B12 is a water-soluble vitamin that plays an important role in brain function and red blood cell production

Best administered on an empty stomach (fasting) for optimal GH release

Once reconstituted with bacteriostatic water, the solution requires refrigeration and should be used within 4 to 6 weeks

Harty PS, Zabriskie HA, Erickson JL, Molling PE, Kerksick CM, Jagim AR

Monitoring: Regular monitoring ensures proper absorption and response

A 1 mg intramuscular injection of hydroxocobalamin every 3 months is the commonest option in both studies and practice, and is recommended by NICE (2022a) in its guidance on management of B12 deficiency