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Gene expression assay via Gpcr in fibroblasts and keratinocytes treated with Astaxanthin and Glutathione

Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

Oxidative stress is closely associated with insulin resistance

doi: 10.1016/0024-3205(86)90482-0

SELENOP is essential for selenium supply to the testes, and animal models lacking the SELENOP gene are infertile due to poor selenium tissue bioavailability, defective GPx4 synthesis, and impaired sperm maturation (7)

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