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Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously

In addition, due to the lack of a long loop between the 4 and 5 helices (residues 112 to 122), the glycinyl group of GSDNB does not interact with the C-domain of GST-, while its dinitrobenzyl group does have hydrophobic contact with Phe106

It has been demonstrated that the substitution of this met residue by another amino acid abrogates or diminishes significantly the prooxidant action of A [50,51]

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doi: 10.1186/s10194-015-0516-6 83