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Melanocortin 2 receptors (MC2Rs) are found in the cortex of the adrenal glands and trigger the production of cortisol by these glands

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[132] [143] [153] Sufficiently overexpressing JunD in the nucleus accumbens with viral vectors can completely block many of the neural and behavioral alterations seen in chronic drug abuse (i.e., the alterations mediated by FosB)