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Pharmacologic inhibition of DNPH1 restores sensitivity to PARP inhibitors in BRCA-mutant cancers and in castration-resistant prostate cancers [249, 250]

The presence of the allele CYP2C9*3 has been associated with reduced clearance of phenytoin
Additionally, its combination with levodopa reduces the peripheral adverse effects of dopamine (e.g., nausea and hypotension) and increases cerebral levodopa bioavailability
Soll, D

Li, J., Han, G., Sun, C
