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Preman, P., Alfonso-Triguero, M., Alberdi, E., Verkhratsky, A

While it is established that large-molecule cytokines, such as IL-17 and TGF-, play a role in immune regulation, small-molecule metabolites with molecular weights ranging from 50 to 1500 Da have the capacity to more readily penetrate cell membranes and modulate CD4 + T cell differentiation pathways

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In living organisms, metabolites are connected to each other through one or multiple metabolic reactions and form the metabolic reaction network that affords the biochemical architecture of cellular metabolism 4

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