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For example, O 2 triggers the intracellular p38 MAPK and JNK pathways, promoting apoptosis while also generating other ROS (such as H 2 O 2 ) to further amplify oxidative damage [218]

To investigate the role of mGluR2/3 receptors, we also assessed whether their pharmacological blockade during NAC treatment would diminish its sustained anti-relapse effectiveness

While some researchers champion their use in drug discovery and personalized medicine, others raise concerns about whether current differentiation protocols can faithfully replicate the intricate in vivo environment of the human brain

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Bertholet-Thomas A, Claramunt-Taberner D, Gaillard S, Deschenes G, Sornay-Rendu E, Szulc P, Cohen-Solal M, Pelletier S, Carlier MC, Cochat P, Bacchetta J (2018) Teenagers and young adults with nephropathic cystinosis display significant bone disease and cortical impairment

Flow cytometry and sorting Flow cytometric analysis was performed using an LSRFortessa cytometer (BD Biosciences), cell sorting was performed using a FACSAria II sorter (BD Biosciences), and all data were analyzed with FlowJo software (Tree Star Inc.)