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Statements Author contributions HK: Writingreview and editing, Writingoriginal draft, Conceptualization

Gastroenterology 103, 16211624

Samples of each type were prepared in 8 replications

These include engineering T cells with enhanced expression of antiapoptotic factors such as Bcl-2 or Bcl-xL to confer resistance to AICD, pharmacological inhibition of ferroptosis using small molecules such as ferrostatin-1 or liproxstatin-1 to preserve T-cell viability under metabolic stress, and combination approaches that simultaneously target cell death pathways and immune checkpoint blockade to prolong T-cell survival and sustain antitumor responses [312]

70, 79, 80 (ii) the transduction of a MOMP-stimulatory signal via the pro-apoptotic BCL-2 family member BAK1, the PTPC component voltage-dependent anion channel 1 (VDAC1) and the BAK1 homolog BAX

Special thanks are also extended to the Comprehensive Research Laboratory and the Center for Breeding and Cultivation of Laboratory Animals at the Jiroft University of Medical Sciences for their invaluable resources and assistance throughout this research
