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A 2019 study found that older adults supplementing high doses of vitamin B12 were at an increased risk of colon cancer

The American Diabetes Association recommends that people on Metformin have their B12 levels checked at least once a year

Nature communications , 11 (1), 5205

Always share your full health history with your provider

The possibility of bruising increases if youre taking a medication or supplement that thins the blood like warfarin, Coumadin, aspirin, fish oil, Ginkgo Biloba, or garlic

a recent safety analysis found no anaphylaxis in hundreds of patients receiving high-dose IV thiamine, suggesting the risk is very low in practice