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They are necessary as the central acting units of extracellular effector and intracellular signaling systems that regulate anti-inflammatory and antioxidant response and the main transcription programs via NF- B and Nrf2, respectively [27]

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doi: 10.1038/nrendo.2013.183 56 BourkeCHHarrellCSNeighGN

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They are also commonly used alongside NAD +1000mg cellular energy support to investigate combined effects on cellular repair and energy efficiency in research environments