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Similarly, the non-transformed non-immortalized human diploid fibroblast cells IMR90 exhibited a significant upregulation of p21 on acute depletion of FH (Fig

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The total length of the gene is about 18.5 kilobases (kb), much of which (about 12 kb) consists of intron 2

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5.2 Antioxidant stress response Oxidative stress is induced by the excessive production of ROS and reactive nitrogen species (RNS), resulting in extensive damage to cellular structures (Patel, 2016)