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Description
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An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD(+) imbalance
Side Effects by Peptide Class Side effects cluster by mechanism of action
Preclinically, cabozantinib was able to inhibit tumor growth, augment the immune response, and increase the immunogenicity in the human immune system (HIS)-BRGS mice implanted with MSS-CRC PDX tumors when combined with the anti-PD-1 mAb nivolumab (Lang et al., 2022)
& Dong, J
(2005) New insights into the physiological actions of selenoproteins from genetically modified mice, IUBMB Life , 57 , 737-744, Conrad, M., and Schweizer, U
