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doi: 10.1111/j.1749-6632.1994.tb44124.x 39 CiprianiG.GibbonsS

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Even though there is evidence that cuprizone could lead to excitotoxicity in oligodendrocytes and neurons, the precise impacts of cuprizone on NMDAR-mediated cell death are not fully understood but could provide a mechanism by which glutamate in the lesion can induce myelin damage (Fig