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Jakinibs are direct inhibitors of the JAK/STAT pathway

The criteria for AIH diagnosis has developed from the report issued by the International AIH Group (IAIHG) in 1993 to the revised one in 1999 [70], and a simplified diagnostic criteria (SDC) was issued in 2008 [64] (Table 1)

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Patients often describe it as a ringing, buzzing, hissing, or pulsating sound, despite no external acoustic source

Thus, the aforementioned findings suggest that the protective effect of IMP on A549 cells may be attributed to its modulation of AHR and ALDH3A1 signaling pathways