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Explor Target Anti-Tumor Ther 1002303

Expression levels were normalized to beta-actin (Actb) and further quantified [1]

[DOI] [PubMed] [Google Scholar] 264.Wang J.C., Bennett M.R

The most prominent ER stress regulators involved in Th1 differentiation is ATF4

What they found: Prevention of age-related changes in gene expression , NMN-treated mice had an expression profile closer to young mice Restoration of mitochondrial function in multiple tissues Improvement of insulin sensitivity of 35 to 50 % Preserved muscle strength and endurance Preserved bone density Better vision (NMN-treated mice had a slower decline in ophthalmologic parameters) No serious adverse effects Why it matters: This is the most ambitious preclinical study of NMN/NAD+ in animal aging models

10.1016/j.cca.2019.12.009 4