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AOD9604 represents part of a broader scientific effort to develop targeted therapies that can isolate beneficial effects of growth hormone while avoiding unwanted systemic effects, similar to the development of selective androgen receptor modulators (SARMs) or selective estrogen receptor modulators (SERMs) in other therapeutic areas

As illustrated in Additional file 1: Figure S1C, animals from both TAT and TAT-DAT NT did not differ in time spent in each duration (two-way ANOVA with repeated measures, F 1, 10 = 0.321, p = NS), suggesting that the differences in spontaneous alternation behavior were unlikely due to confounding factors such as anxiety