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182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

Glutathione peroxidase 4 (GPX-4) is important for regulating the ROS and prevents the buildup of the lipid peroxides, by reducing hydrogen peroxide (H 2 O 2 )

Vaginal extracellular vesicles impair fertility in endometriosis by favoring Th17/Treg imbalance and inhibiting sperm activity

2020;2:e474e484

In line with these predictions, Fh1 / cells exhibited a significant overexpression of Slc7a11, a member of the cystine transporter xCT, which was functionally associated with increased uptake of cystine (Fig