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For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions

doi: 10.1007/s003950050167

Fear avoidance beliefs are theorized to serve as a mediator between avoidance behaviors and subsequent issues such as fatigue and social impairment

The use of Generalized Linear Mixed Models in the study has allowed for more comprehensive data analysis, considering additional covariates and their potential interactions throughout the treatment

The role of sphingolipids in psychoactive drug use and addiction

References Kendler BS: Carnitine: an overview of its role in preventive medicine